Daniel WeSche

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Daniel Wesche

I received a BS degree in Molecular Life Science (2011) and a MS degree in Molecular Mechanisms of Disease (2013) from Radboud University Nijmegen, Netherlands. During my undergraduate studies I worked with Ben Berkhout, Academic Medical Centre Amsterdam, on mother-to-child transmission of HIV and the components of mother’s milk that inhibit transmission.
I started my MS with researching Aquaporin 2 trafficking in the collecting duct of the kidney in Peter Deen’s laboratory at Nijmegen Centre for Molecular Life Sciences. For my MS thesis work, I joined the laboratory of Konrad Hochedlinger at Massachusetts General Hospital to study the role of epigenetic modulators, both proteins and long non-coding (lnc)RNAs, in transcription factor-mediated reprogramming to pluripotency.
My research interests are embryonic and adult stem cells, and the epigenetic mechanisms of cell identity determination during development. I am particularly intrigued by directed cell fate conversions using (trans-)differentiation and reprogramming, and I would like to apply genome-wide profiling and bioinformatics methods to develop novel protocols for targeted differentiation. Ultimately, I hope to aid the development of autologous cell therapies for the treatment of hematologic disorders.