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Majeti Laboratories

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Ravindra
Majeti

MD,PhD

Ravindra Majeti

The Majeti lab focuses on the molecular/genomic characterization and therapeutic targeting of leukemia stem cells in human hematologic disorders, particularly acute myeloid leukemia (AML). We are also interested in developing a similar characterization of normal human hematopoiesis and hematopoietic stem cells. A major focus of the lab is the identification of cell surface molecules preferentially expressed on leukemia stem cells and the development of therapeutic monoclonal antibodies targeting these proteins. Toward this goal, together with Irv Weissman, the lab is actively developing an anti-CD47 antibody for clinical trials in human AML.

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Recent Publications

CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Majeti R, Chao MP, Alizadeh AA, Pang WW, Jaiswal S, Gibbs KD, van Rooijen N, Weissman IL. Cell. 2009; 138 (2): 286-99

Dysregulated gene expression networks in human acute myelogenous leukemia stem cells. Majeti R, Becker MW, Tian Q, Lee TL, Yan X, Liu R, Chiang JH, Hood L, Clarke MF, Weissman IL. Proc Natl Acad Sci U S A. 2009; 106 (9): 3396-401

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Video

RM from Christopher Vaughan on Vimeo.

Contact Info

Institute for Stem Cell Biology and Regenerative Medicine
1050 Arastradero Road, A152
Palo Alto, California 94304

Phone: (650) 721-6376

rmajeti@stanford.edu

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