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Kyle
Loh
PhD

Kyle Loh

Our goal is to understand how various human tissues are constructed from stem cells during development: we apply reductionist approaches to developmental biology. We are delineating a roadmap for early human tissue development by defining the branching lineage choices through which human embryonic and induced pluripotent stem cells develop into >20 different tissue progenitors. At each branching lineage choice where stem cells choose to differentiate into one of two lineages, we are discovering the extracellular cues that induce one cell-type or another. By applying a combination of the relevant inductive signals while blocking the repressive signals that otherwise induce the alternate fate, we can "force" stem cells to differentiate into a relatively pure population of a given cell-type - thus fulfilling a key goal of regenerative medicine. This has allowed us to generate enriched populations of human liver, bone and heart progenitors from pluripotent stem cells, each of which could regenerate their cognate human tissue in respective mouse models. Our current objectives are two-fold: (1) to reconstitute the development of relatively pure populations of human tissue progenitors in vitro for regenerative medicine and (2) to understand the molecular basis of the developmental competence of stem cells and how they subsequently assemble into tissues.

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News Releases

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Recent Publications

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  • Generating Cellular Diversity and Spatial Form: Wnt Signaling and the Evolution of Multicellular Animals. Developmental cell Loh, K. M., van Amerongen, R., Nusse, R.2016; 38 (6): 643-655More

  • Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types CELLLoh, K. M., Chen, A., Koh, P. W., Deng, T. Z., Sinha, R., Tsai, J. M., Barkal, A. A., Shen, K. Y., Jain, R., Morganti, R. M., Shyh-Chang, N., Fernhoff, N. B., George, B. M., Wernig, G., Salomon, R. E., Chen, Z., Vogel, H., Epstein, J. A., Kundaje, A., Talbot, W. S., Beachy, P. A., Ang, L. T., Weissman, I. L.2016; 166 (2): 451-467More

  • Ex uno plures: molecular designs for embryonic pluripotency. Physiological reviewsLoh, K. M., Lim, B., Ang, L. T.2015; 95 (1): 245-295More

  • Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control. Science Clevers, H., Loh, K. M., Nusse, R.2014; 346 (6205)More

  • Efficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations. Cell stem cellLoh, K. M., Ang, L. T., Zhang, J., Kumar, V., Ang, J., Auyeong, J. Q., Lee, K. L., Choo, S. H., Lim, C. Y., Nichane, M., Tan, J., Noghabi, M. S., Azzola, L., Ng, E. S., Durruthy-Durruthy, J., Sebastiano, V., Poellinger, L., Elefanty, A. G., Stanley, E. G., Chen, Q., Prabhakar, S., Weissman, I. L., Lim, B.2014; 14 (2): 237-252More

  • A Precarious Balance: Pluripotency Factors as Lineage Specifiers CELL STEM CELLLoh, K. M., Lim, B.2011; 8 (4): 363-369

 

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Video

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Contact Info

Address here
Palo Alto, California 94304

Phone: (650) 736-1482

tpalmer@stanford.edu
klamont@stanford.edu

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