Stanford

Nakauchi Laboratories

home // FACULTY AND STAFF // Nakauchi Laboratories

  • ABOUT
  • VIDEO
  • NEWS RELEASE
  • RECENT PUBLICATIONS
  • CONTACT INFO

Hiromitsu Nakauchi

MD,PhD

Hiromitsu Nakauchi

In the Nakauchi Lab, we are working on uncovering new diseases, elucidating the causes of disease, and developing therapeutic modalities by connecting the knowledge and methodology of basic science including immunology, molecular biology, cell biology, and developmental engineering with clinical medicine.  Our ultimate goal is to contribute to establishing new frontiers of stem cell therapy and to make clinical applications of stem cells a reality.
Current work in the Nakauchi Lab includes;
1. Elucidation of heterogeneity and hierarchy in hematopoietic stem cells
2. Rejuvenation of antigen specific T cells for efficient immunotherapy
3. Generation of organs from iPS cells by way of blastocyst complementation

With respect to education, we aim to establish an environment where individuals can make the utmost use of their interests, personalities and abilities in order to foster potential researchers, as a human resource, with a succession of creative studies in the field of bioscience.

Back to Top

Video

Back to Top

News Releases

 

Back to Top

Recent Publications

  1. Yamamoto R, Morita Y, Ooehara J, Hamanaka S, Onodera M, Rudolph KL, Ema H, Nakauchi H. Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells. Cell. 2013 Aug 29;154(5):1112-26. doi: 10.1016/j.cell.2013.08.007. PMID: 23993099
  2. Matsunari H, Nagashima H, Watanabe M, Umeyama K, Nakano K, Nagaya M, Kobayashi T, Yamaguchi T, Sumazaki R, Herzenberg LA, Nakauchi H. Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4557-62. doi: 10.1073/pnas.1222902110. Epub 2013 Feb 19. PMID: 23431169
  3. Nishimura T, Kaneko S, Kawana-Tachikawa A, Tajima Y, Goto H, Zhu D, Nakayama-Hosoya K, Iriguchi S, Uemura Y, Shimizu T, Takayama N, Yamada D, Nishimura K, Ohtaka M, Watanabe N, Takahashi S, Iwamoto A, Koseki H, Nakanishi M, Eto K, Nakauchi H. Generation of rejuvenated antigen-specific T cells by pluripotency reprogramming and dedifferentiation. Cell Stem Cell. 12: 114-126m 2013
  4. Yamazaki S, Ema H, Karlsson G, Yamaguchi T, Miyoshi H, Shioda S, Taketo MM, Karlsson S, Iwama A, Nakauchi H. Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell. 2011 Nov 23; 147(5):1146-58.
  5. Kobayashi T, Yamaguchi T, Hamanaka S, Kato-Itoh M, Yamazaki Y, Ibata M, Sato H, Lee YS, Usui J, Knisely AS, Hirabayashi M, Nakauchi H. Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells. Cell. 2010 3; 142:787-99.

 

Back to Top

Contact Info

Institute for Stem Cell Biology & Regenerative Medicine
265 campus Dr.
Stanford, California 94305


nakauchi@stanford.edu

Back to Top